Acetone → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1606535Notes

Reaction equation

[Cl-].[NH4+].[CH3:3][C:4]1[CH2:9][C:8]([CH3:11])([CH3:10])[NH:7][C:6]([CH3:13])([CH3:12])N=1.CC(C)=[O:16]>>[CH3:12][C:6]1([CH3:13])[NH:7][C:8]([CH3:11])([CH3:10])[CH2:9][C:4](=[O:16])[CH2:3]1

Participants

Reactant 3

HCID 180Acetone

HCID 25517Ammonium Chloride

HCID 68396Pyrimidine, 1,2,5,6-tetrahydro-2,2,4,6,6-pentamethyl-

Product 1

HCID 132202,2,6,6-Tetramethyl-4-piperidone

Procedure

17.2 g of acetonine hydrate, 30 g of acetone and 0.5 g of ammonium chloride are heated in a sealed tube for 6 hours at 45° C. After this period of time, it is shown by gas-chromatographical analysis that at least 95% of the employed acetonine has been reacted to form triacetoneamine, which is then isolated by distillation.

Workup

customhas been reacted

Sources & evidence

ORD record: ord-bc183cf9932a450e895a0ba5592890c9
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03953459

Reaction notes

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