Sodium Hydroxide → HCID 86733340, compound

HRID 1606573Notes

Reaction equation

HRID 1606573 reaction equation
[C:1]([C:3]1[C:7]([CH3:8])=[C:6]([CH3:9])[S:5][C:4]=1[NH:10][C:11](=[O:17])[C:12]([O:14]CC)=[O:13])#[N:2].[OH-].[Na+:19]>O>[C:1]([C:3]1[C:7]([CH3:8])=[C:6]([CH3:9])[S:5][C:4]=1[NH:10][C:11](=[O:17])[C:12]([O-:14])=[O:13])#[N:2].[Na+:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 319445Ethyl [(3-cyano-4,5-dimethylthiophen-2-yl)amino](oxo)acetate

Product 1

HCID 86733340HCID 86733340, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Approximately 0.756 g. (0.003 mole) of the purified ethyl (3-cyano-4,5-dimethylthiophen-2-yl)oxamate is suspended in 20 ml. of water and hydrolyzed by the addition of 32 ml. of 0.1N NaOH in a dropwise manner during about twenty minutes. The hydrolysis mixture is stirred for an additional twenty minutes at room temperature. The clear yellow solution (pH 9.2) is adjusted to pH 8.3 with 2 ml. of 0.1N HCl and concentrated in vacuo to recover the sodium salt of (3-cyano-4,5-dimethylthiophen-2-yl)oxamic acid as a yellow solid.

Workup

  1. concentrationof 0.1N HCl and concentrated in vacuo
  2. customto recover the sodium salt of (3-cyano-4,5-dimethylthiophen-2-yl)oxamic acid as a yellow solid

Sources & evidence

ORD record
ord-d30f86d7a7e04238b3840005c125e5d6
Source dataset
uspto-grants-1976_04
Patent number
US03953468

Reaction notes

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