Sodium Hydroxide → HCID 86733340, compound

Participants

Reaction Steps

Approximately 0.756 g. (0.003 mole) of the purified ethyl (3-cyano-4,5-dimethylthiophen-2-yl)oxamate is suspended in 20 ml. of water and hydrolyzed by the addition of 32 ml. of 0.1N NaOH in a dropwise manner during about twenty minutes. The hydrolysis mixture is stirred for an additional twenty minutes at room temperature. The clear yellow solution (pH 9.2) is adjusted to pH 8.3 with 2 ml. of 0.1N HCl and concentrated in vacuo to recover the sodium salt of (3-cyano-4,5-dimethylthiophen-2-yl)oxamic acid as a yellow solid.

Provenance & Evidence