Ethanol → HCID 21544130, compound

HRID 1606631Notes

Reaction equation

HRID 1606631 reaction equation
[CH2:1]([OH:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[I:10][C:11]1[C:19]([C:20]([NH:22][CH3:23])=[O:21])=[C:18]([I:24])[C:17]([NH:25][C:26](=[O:30])[CH2:27][O:28][CH3:29])=[C:16]([I:31])[C:12]=1[C:13](Cl)=[O:14]>>[I:10][C:11]1[C:19]([C:20]([NH:22][CH3:23])=[O:21])=[C:18]([I:24])[C:17]([NH:25][C:26](=[O:30])[CH2:27][O:28][CH3:29])=[C:16]([I:31])[C:12]=1[C:13]([O:3][CH2:1][CH3:2])=[O:14]

Participants

4

Reactant 3

HCID 702EthanolHCID 11430Potassium CarbonateHCID 21544131HCID 21544131, compound2×

Product 1

HCID 21544130HCID 21544130, compound

Procedure

A solution of 2,4,6-triiodo-5-methoxyacetamido-N-methylisophthalamoyl chloride in N,N-dimethylacetamide (prepared as in Example 3) is treated with absolute ethanol in the presence of potassium carbonate. After the reaction is complete, the inorganic salts are removed by filtration and the filtrate is evaporated to dryness to provide ethyl 2,4,6-triiodo-5-methoxyacetamido-N-methylisophthalamate.

Workup

  1. customthe inorganic salts are removed by filtration
  2. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-14dd052dc26248b1a3df885708f17ca9
Source dataset
uspto-grants-1976_04
Patent number
US03953497

Reaction notes

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