反应详情

15 ml. of liquid methylamine is added at 0° C. to 42.3 g. (0.15 mole) of N-(3-methoxycarbonyl-5-nitrobenzoyl)-glycine (VIa) in 150 ml. of methanol; the reaction mixture is stored for 3 days at room temperature. Then, the mixture is concentrated to dryness under vacuum, and the residue is refluxed with absolute alcohol. After cooling, the reaction mixture is filtered, washed with alcohol and dried under vacuum. Yield: 43.2 g. M.P. 216°-217°C.

1. concentrationThen, the mixture is concentrated to dryness under vacuum
2. temperaturethe residue is refluxed with absolute alcohol
3. temperatureAfter cooling
4. filtrationthe reaction mixture is filtered
5. washwashed with alcohol
6. customdried under vacuum