Acetyl chloride → HCID 21427307, compound

HRID 1606666Notes

Reaction equation

HRID 1606666 reaction equation
[CH3:1][NH:2][C:3](=[O:22])[CH2:4][CH2:5][NH:6][C:7](=[O:21])[C:8]1[C:13]([I:14])=[C:12]([NH2:15])[C:11]([I:16])=[C:10]([C:17]([OH:19])=[O:18])[C:9]=1[I:20].CNC(=O)C(CO)NC(=O)C1C(I)=C(N)C(I)=[C:31]([C:38](O)=[O:39])C=1I.C(Cl)(=O)C>CC(N(C)C)=O>[CH3:1][NH:2][C:3](=[O:22])[CH2:4][CH2:5][NH:6][C:7](=[O:21])[C:8]1[C:13]([I:14])=[C:12]([NH:15][C:38](=[O:39])[CH3:31])[C:11]([I:16])=[C:10]([C:17]([OH:19])=[O:18])[C:9]=1[I:20]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 21427255HCID 21427255, compoundHCID 21427284HCID 21427284, compound

Product 1

HCID 21427307HCID 21427307, compoundYield 58.8%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

99.5 g. (0.15 mole) of N-(3-carboxy-5-amino-2,4,6-triiodobenzoyl)-β-alanine methylamide . 1.1 H2O (IV f), m.p. 250°-252° C. (decomposition) in 190 ml. of dimethylacetamide yield, after reaction with 40.0 ml. of acetyl chloride analogously to Example 1, 60.4 g. (58.8%) of the desired compound. A sample for analysis is purified in alcohol by way of the dimethylammonium salt; m.p. 288°-289° C. (under decomposition).

Workup

  1. customafter reaction with 40.0 ml

Sources & evidence

ORD record
ord-a438939ffbd84d41b4ab2a2d625c2a4f
Source dataset
uspto-grants-1976_04
Patent number
US03953501

Reaction notes

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