Methyl iodide → 3-Methoxy-5-(trifluoromethyl)benzoic acid

HRID 1606764Notes

Reaction equation

HRID 1606764 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH3:15]I.C[O-].[Na+]>CO>[CH3:15][O:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:10]=1)[C:5]([OH:7])=[O:6]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 27831463-hydroxy-5-(trifluoromethyl)benzoic AcidHCID 10942334Sodium Methoxide

Product 1

HCID 215444673-Methoxy-5-(trifluoromethyl)benzoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This product is prepared according to the procedure of Example 5 and comprises contacting 3-hydroxy-5-trifluoromethylbenzoic acid with methyl iodide in methanol containing sodium methoxide as the base, m.p. 131°-135° C.

Workup

  1. customThis product is prepared

Sources & evidence

ORD record
ord-b92fa04e02ba4fd087351bc967c99679
Source dataset
uspto-grants-1976_04
Patent number
US03953595

Reaction notes

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