Nicotinic Acid → 3-Pyridinecarbonyl chloride, hydrochloride (1:1)

HRID 1606783Notes

Reaction equation

HRID 1606783 reaction equation
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.S(Cl)([Cl:12])=O>>[ClH:12].[C:1]([Cl:12])(=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 24386Thionyl Chloride

Product 1

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

Procedure

A mixture of 90 grams of nicotinic acid and 180 ml of thionyl chloride were heated at 55°-65° C. for 3.5 hours. The excess thionyl chloride was removed in vacuum and nicotinoyl chloride-hydrochloride was obtained

Workup

  1. temperaturewere heated at 55°-65° C. for 3.5 hours
  2. customThe excess thionyl chloride was removed in vacuum

Sources & evidence

ORD record
ord-5df2b4ef3cbd4979a0997afef0064690
Source dataset
uspto-grants-1976_04
Patent number
US03953596

Reaction notes

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