HRID1606822

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1

HCID178501487

未命名化合物

PRODUCTS

生成物

结构：O=C1CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CO)C(=O)O)N1

HCID178516176

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of L-pyroglutamyl-L-histidyl-L-tryptophyl-L-serine methyl ester (VI) (0.553 g) in absolute methanol (50 ml) containing sodium hydroxide (40 mg) is stirred at room temperature for 2 hours. The reaction mixture is then neutralized to pH 7.5 with dilute hydrochloric acid and evaporated to dryness. The solid residue is triturated thoroughly in absolute methanol and filtered. The filtrate is evaporated to the tetrapeptide VII.

WORKUP

后处理

customevaporated to dryness
customThe solid residue is triturated thoroughly in absolute methanol
filtrationfiltered
customThe filtrate is evaporated to the tetrapeptide VII

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-efa40975181d4146818b5e360d293c01
来源数据集: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03953416
来源说明: uspto-grants-1976_04

反应 SMILES

C[O:2][C:3](=[O:40])[C@H:4]([CH2:38][OH:39])[NH:5][C:6](=[O:37])[C@H:7]([CH2:27][C:28]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[NH:30][CH:29]=1)[NH:8][C:9](=[O:26])[C@H:10]([CH2:20][C:21]1[N:25]=[CH:24][NH:23][CH:22]=1)[NH:11][C:12](=[O:19])[C@@H:13]1[CH2:17][CH2:16][C:15](=[O:18])[NH:14]1.[OH-].[Na+].Cl>CO>[NH:14]1[C:15](=[O:18])[CH2:16][CH2:17][C@H:13]1[C:12]([NH:11][C@H:10]([C:9]([NH:8][C@H:7]([C:6]([NH:5][C@H:4]([C:3]([OH:40])=[O:2])[CH2:38][OH:39])=[O:37])[CH2:27][C:28]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[NH:30][CH:29]=1)=[O:26])[CH2:20][C:21]1[N:25]=[CH:24][NH:23][CH:22]=1)=[O:19]