Hydrochloric Acid → HCID 19851585, compound

HRID 1607016Notes

Reaction equation

HRID 1607016 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:22])[N:9](C)[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]([O:18]CC)=[O:17])[C:6]=2[CH:5]=[CH:4][C:3]=1[F:23].[OH-].[Na+].Cl>C(O)C.O>[Cl:1][C:2]1[C:7]2[C:8](=[O:22])[NH:9][CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]([OH:18])=[O:17])[C:6]=2[CH:5]=[CH:4][C:3]=1[F:23]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22914361HCID 22914361, compound

Product 1

HCID 19851585HCID 19851585, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

14.55 g (43 mmol) of ethyl 7-chloro-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate was heated to boiling under reflux for 15 minutes with 1.90 g (45.7 mmol) of sodium hydroxide in 80 ml of ethanol and 30 ml of water. The reaction mixture was then cooled and treated with 10.4 ml of 4N hydrochloric acid. By suction filtering the suspension obtained and drying the product there was obtained 7-chloro-8-fluoro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid of decomposition point 260°.

Workup

  1. temperatureThe reaction mixture was then cooled
  2. filtrationBy suction filtering the suspension
  3. customobtained
  4. customdrying the product there

Sources & evidence

ORD record
ord-c643cfbb8be74c87b8436cfe71401fc3
Source dataset
uspto-grants-1989_09
Patent number
US04863920

Reaction notes

Loading…