Sec-Butylamine → HCID 19851808, compound
Reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[NH:8][CH2:9][CH2:10][S:11][C:12]([O:14]C2C=CC([N+]([O-])=O)=CC=2)=O)C=CC=CC=1.[CH:36]([NH2:40])([CH2:38][CH3:39])[CH3:37]>>[CH:36]([NH:40][C:12]([S:11][CH2:10][CH2:9][NH2:8])=[O:14])([CH2:38][CH3:39])[CH3:37]Participants
3
Procedure
N-triphenylmethyl-2-paranitrophenoxycarbonylthioethylamine (300 mg) and sec-butylamine (188 μl) were subjected to similar reactions to those described in References 2 and 4 to give 2-sec-butylaminocarbonylthioethylamine (crude formate: 227 mg). The product was dissolved in anhydrous methanol (5 ml). Triethylamine (342 μl) and mitomycin A (137 mg: 0.8 molar equivalent) were added to the reaction solution which was then treated in a similar manner to that described in Example 1 to obtain Compound 30 (94 mg) in the form of grayish blue powders with a yield of 49%.
Sources & evidence
- ORD record
- ord-38e819ae3cb3448ca764031cfba4b73a
- Source dataset
- uspto-grants-1989_09
- Patent number
- US04863935
Reaction notes
Loading…