Sec-Butylamine → HCID 19851808, compound

Participants

Reaction Steps

N-triphenylmethyl-2-paranitrophenoxycarbonylthioethylamine (300 mg) and sec-butylamine (188 μl) were subjected to similar reactions to those described in References 2 and 4 to give 2-sec-butylaminocarbonylthioethylamine (crude formate: 227 mg). The product was dissolved in anhydrous methanol (5 ml). Triethylamine (342 μl) and mitomycin A (137 mg: 0.8 molar equivalent) were added to the reaction solution which was then treated in a similar manner to that described in Example 1 to obtain Compound 30 (94 mg) in the form of grayish blue powders with a yield of 49%.

Provenance & Evidence