Piperidine → HCID 19851804, compound

Participants

Reaction Steps

N-triphenylmethyl-2-paranitrophenoxycarbonylthioethylamine (300 mg) and piperidine (184 μl) were subjected to similar reations to those described in References 2 and 4 to give 2-piperidinocarbonylthioethylamine (crude formate: 137 mg). The product was dissolved in anhydrous methanol (3 ml). To the solution were added triethylamine (432 μl) and mitomycin A (151 mg: 0.7 molar equivalent). The solution was treated in a similar manner to that described in Example 1 to obtain Compound 42 (0.21 mg) in the form of grayish blue powders with a yield of 74%.

Provenance & Evidence