Piperidine → HCID 19851804, compound

HRID 1607097Notes

Reaction equation

HRID 1607097 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[NH:8][CH2:9][CH2:10][S:11][C:12](OC2C=CC([N+]([O-])=O)=CC=2)=[O:13])C=CC=CC=1.[NH:36]1[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1>>[N:36]1([C:12]([S:11][CH2:10][CH2:9][NH2:8])=[O:13])[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 15616513HCID 15616513, compound

Product 1

HCID 19851804HCID 19851804, compound

Procedure

N-triphenylmethyl-2-paranitrophenoxycarbonylthioethylamine (300 mg) and piperidine (184 μl) were subjected to similar reations to those described in References 2 and 4 to give 2-piperidinocarbonylthioethylamine (crude formate: 137 mg). The product was dissolved in anhydrous methanol (3 ml). To the solution were added triethylamine (432 μl) and mitomycin A (151 mg: 0.7 molar equivalent). The solution was treated in a similar manner to that described in Example 1 to obtain Compound 42 (0.21 mg) in the form of grayish blue powders with a yield of 74%.

Sources & evidence

ORD record
ord-d15e3525968a4b56a982658e5bdb5952
Source dataset
uspto-grants-1989_09
Patent number
US04863935

Reaction notes

Loading…