Hydrochloric Acid → HCID 19898957, compound

HRID 1607117Notes

Reaction equation

HRID 1607117 reaction equation
[C:1]1(=[O:22])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][N:2]1[CH:11](CC1C=CC=CC=1)[CH2:12][NH:13][CH3:14].[ClH:23]>C(O)C.[Pd]>[ClH:23].[C:1]1(=[O:22])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][N:2]1[CH2:11][CH2:12][NH:13][CH3:14]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86743362HCID 86743362, compound

Product 1

HCID 19898957HCID 19898957, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2-(2H-phthalazin-1-on-2-yl)-N-methyl-N-benzylethylamine (41.5 g) in ethanol (1000 ml) and concentrated hydrochloric acid (50 ml) containing 5% palladium on charcoal (4.1 g) was stirred under a hydrogen atmosphere (50 p.s.i.) at room temperature for 18 hours. The reaction mixture was filtered and evaporated to afford a solid which was recrystallised from isopropanol to afford the title compound, yield 22.5 g, m.p. 200°-201°.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated
  3. customto afford a solid which
  4. customwas recrystallised from isopropanol

Sources & evidence

ORD record
ord-889b81ec8872419e89399440d46f526b
Source dataset
uspto-grants-1989_09
Patent number
US04863948

Reaction notes

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