Hydrochloric Acid → HCID 14234808, compound
Reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.[Cl-].[Al+3].[Cl-].[Cl-].[C:14]1(=[O:20])[O:19][C:17](=[O:18])[CH2:16][CH2:15]1.Cl>ClC(Cl)C.O>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:14](=[O:20])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:9][C:4]=2[CH2:3][CH2:2]1Participants
Conditions
- Temperature
- 5 °C
Procedure
A suspension, cooled to 0° C., of 120 g of 2,3-di-hydrobenzofuran and 128 g of aluminum chloride in 260 ml of dichloroethane is added to a mixture of 96 g of succinic anhydride and 260 g of aluminum chloride in 512 ml of dichloroethane. The temperature is maintained at approximately 5° C. The reaction medium, maintained for 2 hours at this temperature, is then poured into a solution of 3 liters of water containing 400 ml of concentrated hydrochloric acid. After separation following settling, and extraction with methylene chloride, the organic phase is exhaustively extracted with 1N sodium hydroxide. The combined basic phases are acidified in the cold with 6N hydrochloric acid and the oil formed is extracted with methylene chloride. The organic phase is washed to neutrality and then dried.
Workup
- temperatureThe reaction medium, maintained for 2 hours at this temperature
- customAfter separation
- extractionextraction with methylene chloride
- extractionthe organic phase is exhaustively extracted with 1N sodium hydroxide
- customthe oil formed
- extractionis extracted with methylene chloride
- washThe organic phase is washed to neutrality
- customdried
Sources & evidence
- ORD record
- ord-1995f0c76be5475e9b921dd8118606ce
- Source dataset
- uspto-grants-1989_09
- Patent number
- US04863951
Reaction notes
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