Hydrochloric Acid → HCID 10679778, compound

HRID 1607132Notes

Reaction equation

HRID 1607132 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11](=O)[CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:10][C:5]=2[CH2:4][CH2:3]1.C1(C)C=CC=CC=1>O.[Zn]>[O:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:10][C:5]=2[CH2:4][CH2:3]1

Participants

6

Reactant 3

HCID 313Hydrochloric Acid2×HCID 1140TolueneHCID 14234808HCID 14234808, compound

Product 1

HCID 10679778HCID 10679778, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 962WaterSolvent

Procedure

300 g of zinc and 30 g of mercuric chloride are added with stirring to a mixture containing 510 ml of concentrated hydrochloric acid in 240 ml of water, 141 g of 4-(2,3-dihydro-5-benzofuranyl)-4-oxobutanoic acid obtained above and 300 ml of toluene. The reaction medium is brought to reflux for 6 hours. 150 ml of concentrated hydrochloric acid are added and refluxing is continued overnight.

Workup

  1. temperatureto reflux for 6 hours
  2. temperaturerefluxing

Sources & evidence

ORD record
ord-c8a675d3acee4735a51e6427e5e3609d
Source dataset
uspto-grants-1989_09
Patent number
US04863951

Reaction notes

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