Hydroxyamine hydrochloride → HCID 72728813, compound

HRID 1607133Notes

Reaction equation

HRID 1607133 reaction equation
[O:1]1[CH2:5][CH2:4][C:3]2[CH:6]=[C:7]3[C:12](=[CH:13][C:2]1=2)[C:11](=O)[CH2:10][CH2:9][CH2:8]3.Cl.[NH2:16][OH:17].C([O-])(=O)C.[Na+]>C(O)C.O>[O:1]1[CH2:5][CH2:4][C:3]2[CH:6]=[C:7]3[C:12](=[CH:13][C:2]1=2)[C:11](=[N:16][OH:17])[CH2:10][CH2:9][CH2:8]3

Participants

6

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 14234809HCID 14234809, compound

Product 1

HCID 72728813HCID 72728813, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture containing 46 g of the compound of Example 1, 60 g of hydroxylamine hydrochloride and 60 g of anhydrous sodium acetate in 410 ml of ethanol is brought to reflux for 5 hours. The mixture is then cooled and diluted with water, extracted with methylene chloride, dried and evaporated to dryness. The dry residue is recrystallized in ethanol.

Workup

  1. temperatureto reflux for 5 hours
  2. temperatureThe mixture is then cooled
  3. extractionextracted with methylene chloride
  4. customdried
  5. customevaporated to dryness
  6. customThe dry residue is recrystallized in ethanol

Sources & evidence

ORD record
ord-59d32ec2dc1847fd9996f6812d1cf8fb
Source dataset
uspto-grants-1989_09
Patent number
US04863951

Reaction notes

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