Potassium Iodide → 1-(3-Bromopropoxy)-3-nitrobenzene

Participants

Reaction Steps

43 ml of 1,3-dibromopropane are added to a suspension of 29 g of potassium carbonate and 0.5 g of potassium iodide in 170 ml of acetone and the whole is heated under reflux. A solution of 19.4 g of 3-nitrophenol is then added dropwise thereto in the course of 2 hours and the whole is heated for a further 15 hours under reflux. The reaction mixture is filtered while hot and concentrated by evaporation. After chromatography of the residue over silica gel using toluene, 3-(3-bromopropoxy)-nitrobenzene is obtained in the form of a light yellow oil.

Provenance & Evidence