Formamide → HCID 178473798, compound

HRID 1607166Notes

Reaction equation

HRID 1607166 reaction equation
Cl.Cl.[C:3]([N:6]1[C:14]2[C:9](=[CH:10][C:11]([NH2:16])=[C:12]([NH2:15])[CH:13]=2)[C:8]([CH3:18])([CH3:17])[CH2:7]1)(=[O:5])[CH3:4].[CH:19](N)=O>>[C:3]([N:6]1[C:14]2=[CH:13][C:12]3[NH:15][CH:19]=[N:16][C:11]=3[CH:10]=[C:9]2[C:8]([CH3:18])([CH3:17])[CH2:7]1)(=[O:5])[CH3:4]

Participants

3

Reactant 2

HCID 713FormamideHCID 19852027HCID 19852027, compound

Product 1

HCID 178473798HCID 178473798, compound

Procedure

A mixture of 3.0 g. (0.01 mole) 1-acetyl-5,6-diamino-3,3-dimethylindoline dihydrochloride (Example 2b) and 35 ml. formamide is heated to reflx for 40 minutes and then evaporated. The residue is mixed with water, extracted with dichloromethane and the extract evaporated to give 2.6 g. (85% of theory) of the title compound; m.p. 214°-216° C.

Workup

  1. additionA mixture of 3.0 g
  2. customevaporated
  3. additionThe residue is mixed with water
  4. extractionextracted with dichloromethane
  5. customthe extract evaporated
  6. customto give 2.6 g

Sources & evidence

ORD record
ord-0667a237e2e745038e5c9e49df4d2828
Source dataset
uspto-grants-1989_09
Patent number
US04863945

Reaction notes

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