1,5-Diazabicyclo(4.3.0)non-5-ene → HCID 14651078, compound

HRID 1607175Notes

Reaction equation

HRID 1607175 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH:18]=[O:19])[C:10]([CH3:17])([CH3:16])[CH2:11][C:12]([CH3:15])([CH3:14])[CH:13]=2)=[CH:4][CH:3]=1.N12CCCC1=NCCC2>C1COCC1.C(O)C.CCOCC>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH2:13][C:12]([CH3:14])([CH3:15])[CH2:11][C:10]([CH3:17])([CH3:16])[C:9]=2[CH:18]=[O:19])=[CH:6][CH:7]=1

Participants

6

Reactant 2

HCID 763491,5-Diazabicyclo(4.3.0)non-5-eneHCID 14651077HCID 14651077, compound

Product 1

HCID 14651078HCID 14651078, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

The aldehyde obtained in Step 5 (130 g, 50 mmoles) was dissolved in a solution of 50 ml of THF and 50 ml of ethanol. To this solution was added 0.62 ml (5 mmles) of 1,5-diaza- bicylo-[4,3,0]-non-5-ene and the reaction mixture stirred at room temperature for 50 hours. The reaction mixture then was diluted with ether and extracted with dilute HCl, saturated NaHCO3, and brine. The solvents were evaporated in vacuo and the residue purified by flash chromatography on silica gel.

Workup

  1. extractionextracted with dilute HCl, saturated NaHCO3, and brine
  2. customThe solvents were evaporated in vacuo
  3. customthe residue purified by flash chromatography on silica gel

Sources & evidence

ORD record
ord-587eddfc84954126bb42dfed8a264b28
Source dataset
uspto-grants-1989_09
Patent number
US04863957

Reaction notes

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