Phosphinic Acid → HCID 14621046, compound

HRID 1607193Notes

Reaction equation

HRID 1607193 reaction equation
N[C:2]1[CH:15]=[CH:14][C:5]([CH:6]([OH:13])[CH2:7][NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[C:4]([F:16])[C:3]=1[F:17].O[PH2]=O>>[C:9]([NH:8][CH2:7][CH:6]([OH:13])[C:5]1[CH:14]=[CH:15][CH:2]=[C:3]([F:17])[C:4]=1[F:16])([CH3:12])([CH3:10])[CH3:11]

Participants

3

Reactant 2

HCID 4124402Phosphinic AcidHCID 14621043HCID 14621043, compound

Product 1

HCID 14621046HCID 14621046, compound

Procedure

By using the procedure of Example 18, 4-amino-α-[(tert-butylamino)methyl]-2,3-difluorobenzyl alcohol is deaminated with H3PO2 to afford the title compound. Similarly, 2,3-difluoro-α-[(isopropylamino)methyl]benzyl alcohol is obtained from its corresponding 4-amino compound.

Sources & evidence

ORD record
ord-4069c74db9e0469589127cd3168bfdbd
Source dataset
uspto-grants-1989_09
Patent number
US04863959

Reaction notes

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