Chlorosuccinimide → HCID 14621052, compound

HRID 1607196Notes

Reaction equation

HRID 1607196 reaction equation
[C:1]([C:4]1[C:10]([F:11])=[CH:9][C:7]([NH2:8])=[C:6]([Cl:12])[CH:5]=1)(=[O:3])[CH3:2].[Cl:13]N1C(=O)CCC1=O>C1(C)C=CC=CC=1>[C:1]([C:4]1[CH:5]=[C:6]([Cl:12])[C:7]([NH2:8])=[C:9]([Cl:13])[C:10]=1[F:11])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 14621049HCID 14621049, compound

Product 1

HCID 14621052HCID 14621052, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In 10 mL of toluene, 0.5 g of 4-acetyl-2-chloro-5-fluoroaniline and 0.42 g of N-chlorosuccinimide are heated at reflux for several hours until the reaction is complete. The mixture is filtered and the filter cake is washed with H2O. The filtrate of the original reaction mixture is concentrated to afford a precipitate which is collected and washed with H2O. The solids are combined to afford the crude title compound, which is used further as is.

Workup

  1. temperatureat reflux for several hours until the reaction
  2. filtrationThe mixture is filtered
  3. washthe filter cake is washed with H2O
  4. concentrationThe filtrate of the original reaction mixture is concentrated
  5. customto afford a precipitate which
  6. customis collected
  7. washwashed with H2O

Sources & evidence

ORD record
ord-45d0e3108d3744bb9548a64dff49ac8c
Source dataset
uspto-grants-1989_09
Patent number
US04863959

Reaction notes

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