Trifluoroacetic acid → HCID 11552535, compound

HRID 16072Notes

Reaction equation

HRID 16072 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9].C(O)(C(F)(F)F)=[O:28]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])(=[O:9])=[O:28]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 866203721,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate

Product 1

HCID 11552535HCID 11552535, compound

Procedure

A solution of the product from step d) (73 mg) in TFA (3 ml) was stirred for 2 h. The solvent was removed in vacuo, water was added and the mixture was extracted with dichloromethane (three times). The organic extracts were dried (MgSO4), evaporated and triturated with ether to give the title compound (46 mg) as a white solid. M.p. 140-2° C.

Workup

  1. customThe solvent was removed in vacuo, water
  2. additionwas added
  3. extractionthe mixture was extracted with dichloromethane (three times)
  4. dry with materialThe organic extracts were dried (MgSO4)
  5. customevaporated
  6. customtriturated with ether

Sources & evidence

ORD record
ord-4d43f8afcb5d4b9f9222be483f1f66a8
Source dataset
uspto-grants-2010_06
Patent number
US07737135B2

Reaction notes

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