Pyridine → 2-(Chloromethyl)-5-nitro-1-benzothiophene

HRID 160720Notes

Reaction equation

HRID 160720 reaction equation
[CH3:25][CH2:26][O:27][C:28](=[O:29])[CH3:30].[Cl:31][CH2:32][Cl:33].[N+:5](=[O:6])([O-:7])[c:8]1[cH:9][c:10]2[c:11]([s:12][c:13]([CH2:15][OH:16])[cH:14]2)[cH:17][cH:18]1.[S:1]([Cl:2])([Cl:3])=[O:4].[cH:19]1[cH:20][cH:21][n:22][cH:23][cH:24]1>>[Cl:3][CH2:15][c:13]1[s:12][c:11]2[c:10]([cH:9][c:8]([N+:5](=[O:6])[O-:7])[cH:18][cH:17]2)[cH:14]1

Participants

6

Reactant 5

HCID 1049PyridineHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 24386Thionyl ChlorideHCID 12182118(5-nitrobenzo[b]thiophen-2-yl)methanol

Product 1

HCID 151337582-(Chloromethyl)-5-nitro-1-benzothiophene

Sources & evidence

ORD record
ord-fb6b370dacf046f98ca6ccab8e570164
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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