Ethanol → HCID 19910740, compound

HRID 1607289Notes

Reaction equation

HRID 1607289 reaction equation
Cl.[OH:2][C:3]1[C:8]2[C:9]([CH3:21])=[C:10]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[O:11][C:7]=2[CH:6]=[CH:5][C:4]=1[CH2:22]N(C)C.C(Br)C.[CH2:29]([OH:31])[CH3:30]>>[OH:2][C:3]1[C:8]2[C:9]([CH3:21])=[C:10]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[O:11][C:7]=2[CH:6]=[CH:5][C:4]=1[CH2:22][O:31][CH2:29][CH3:30]

Participants

4

Reactant 3

HCID 702EthanolHCID 6332Ethyl BromideHCID 19910761HCID 19910761, compound

Product 1

HCID 19910740HCID 19910740, compound

Procedure

A mixture of (177) (Example 45) (0.1 g, 0.28 mmol), ethyl bromide, (1 mL) and ethanol (5 mL) was refluxed for 6 h. The solvent was evaporated, the residue was chromatographed on preparative tlc to give the title compound.

Workup

  1. temperaturewas refluxed for 6 h
  2. customThe solvent was evaporated
  3. customthe residue was chromatographed on preparative tlc

Sources & evidence

ORD record
ord-c8b9dfa03a3a4637b59b8e3bf6db8434
Source dataset
uspto-grants-1989_09
Patent number
US04863958

Reaction notes

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