反应详情

温度

40 °C

To a solution of 0.30 g of 3'-O-(4-chlorobenzyl)-5'-O-acetyl-2'-deoxy-5-fluorouridine in 30 ml of dioxane were added 0.38 g of 4-chlorobenzoyl chloride and 0.61 ml of triethylamine, and the mixture was stirred at 40° C. for 3 hours. The insolubles were removed by filtration, and the residue was dissolved in 50 ml of ethyl acetate. The solution was washed with water and dried. The ethyl acetate was distilled off, and the residue was placed on a silica gel column and eluted with chloroform-n-hexane (3:2), thereby producing 0.33 g of the title compound in a yield of 82%.

1. customThe insolubles were removed by filtration
2. dissolutionthe residue was dissolved in 50 ml of ethyl acetate
3. washThe solution was washed with water
4. customdried
5. distillationThe ethyl acetate was distilled off
6. washeluted with chloroform-n-hexane (3:2)