HCID 348326, compound → HCID 12308369, compound

HRID 1607406Notes

Reaction equation

HRID 1607406 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[C:5]([C:17]#[N:18])=[CH:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][CH:8]=1)[CH3:2]>C1C=CC=CC=1.[Pd]>[CH2:1]([O:3][C:4](=[O:19])[CH:5]([C:17]#[N:18])[CH2:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][CH:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 348326HCID 348326, compound

Product 1

HCID 12308369HCID 12308369, compoundYield 99.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 241BenzeneSolvent

Procedure

A solution of 13.6 g of the ester compound obtained in 300 ml of benzene was hydrogenated over 1.3 g of a 10% palladium/charcoal under atmospheric pressure. After filtration of the catalyst, the filtrate was concentrated under reduced pressure to obtain 13.6 g of 2-cyano-3-(1-naphthyl)propionic acid ethyl ester as a colorless oil.

Workup

  1. filtrationAfter filtration of the catalyst
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-12c5fd5e0a2745a4a322e1206979e939
Source dataset
uspto-grants-1989_09
Patent number
US04863904

Reaction notes

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