2-(6-Methoxy-2-naphthyl)propionic acid → 2-(6-Methoxynaphthalen-2-yl)propanoic acid--ethanamine (1/1)
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:7]=[CH:6]2.[CH2:18]([NH2:20])[CH3:19]>CC(C)=O>[CH2:18]([NH2:20])[CH3:19].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:7]=[CH:6]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
230 g (1 mole) of (±)-2-(6-methoxy-2-naphthyl) propionic acid was dissolved in 1.5 l of acetone at about 45° C. By addition of 64 g (1 mole) of a 70% w/w aqueous monoethylamine solution, the ethylamine salt crystallized. The mixture was cooled to about 25° C., filtered and washed portionwise with 200 ml of acetone.
Workup
- customthe ethylamine salt crystallized
- filtrationfiltered
- washwashed portionwise with 200 ml of acetone
Sources & evidence
- ORD record
- ord-2285ac221bcd47ad96639dd2f910b1c6
- Source dataset
- uspto-grants-1989_09
- Patent number
- US04865770
Reaction notes
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