Methylamine → HCID 19850799, compound

HRID 1607521Notes

Reaction equation

HRID 1607521 reaction equation
[C:1]1([C:7]2[C:8]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:9]([NH:12][C:13]([NH:15][CH3:16])=[O:14])[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N[C:23]1SC=C(C2C=CC=CC=2)C=1C(OCC)=O.CN.C(N)C>>[CH2:16]([NH:15][C:13](=[O:14])[NH:12][C:9]1[S:10][CH:11]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]=1[C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH3:23]

Participants

5

Reactant 4

HCID 6329MethylamineHCID 6341EthylamineHCID 73242Ethyl 2-amino-4-phenylthiophene-3-carboxylateHCID 13742728HCID 13742728, compound

Product 1

HCID 19850799HCID 19850799, compound

Procedure

In exactly the same manner ethyl 4-phenyl-2-(N'-methylureido)thiophene-3-carboxylate. m.p. 109°-12° C. and ethyl 2-(N'-ethylureido)-4-phenyl-thiophene-3-carboxylate M.p. 129°-33° C. were prepared from ethyl 2-amino-4-phenyl-thiophene-3-carboxylate (Gewald et. al., Chem. Ber. 99, 94 (1966) and methylamine and ethylamine respectively.

Sources & evidence

ORD record
ord-1fd962cce82e4357901e090652081119
Source dataset
uspto-grants-1989_09
Patent number
US04866065

Reaction notes

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