Acetic Acid → HCID 15085580, compound

HRID 1607524Notes

Reaction equation

HRID 1607524 reaction equation
[CH3:1][NH:2][C:3](=[O:14])[NH:4][C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10](OC)=[O:11].CN(C)C=O.C(O)(=O)C>[OH-].[K+]>[CH3:1][N:2]1[C:10](=[O:11])[C:6]2[S:7][CH:8]=[CH:9][C:5]=2[NH:4][C:3]1=[O:14]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6228DimethylformamideHCID 15085579HCID 15085579, compound

Product 1

HCID 15085580HCID 15085580, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

Methyl 3-(N'-methylureido)thiophene-2-carboxylate (4,2 g, 20 mmol) was suspended with stirring in 5% aqueous potassium hydroxide (50 ml). Dimethylformamide was added until a clear solution was obtained. Stirring was continued for 30 min, whereafter the solution was neutralized with acetic acid. This afforded a crystalline precipitate of the title compound, which was separated by filtration and washed with water. M.p.>300° C.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-f9681ba618da4a4bbc084a425f84d94f
Source dataset
uspto-grants-1989_09
Patent number
US04866065

Reaction notes

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