N'-Hydroxycyclopropanecarboximidamide → 4,5-Dihydro-5-methyl-6-(3-methyl-1,2,4-oxadiazol-5-yl)-4-oxo-imidazo[1,5-a]thieno[3,2-e]pyrimidine

HRID 1607527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1607527
[CH:1]1([C:4]2[N:8]=[C:7]([C:9]3[N:10]=[CH:11][N:12]4[C:17]5[S:18][CH:19]=[CH:20][C:16]=5[C:15](=[O:21])[N:14]([CH3:22])[C:13]=34)[O:6][N:5]=2)CC1.CN1C(=O)C2C=CSC=2N2C=NC(C(OCC)=O)=C12.C1(C(=NO)N)CC1>>[CH3:22][N:14]1[C:15](=[O:21])[C:16]2[CH:20]=[CH:19][S:18][C:17]=2[N:12]2[CH:11]=[N:10][C:9]([C:7]3[O:6][N:5]=[C:4]([CH3:1])[N:8]=3)=[C:13]12

Komponenten

4

Edukt 3

HCID 2794666N'-Hydroxycyclopropanecarboximidamide2×HCID 15085581Ethyl 4,5-dihydro-5-methyl-4-oxo-imidazo[1,5-a]thieno[3,2-e]pyrimidine-6-carboxylateHCID 150855906-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-4,5-dihydro-5-methyl-4-oxo-imidazo[1,5-a]thieno[3,2-e]pyrimidine

Produkt 1

HCID 150855894,5-Dihydro-5-methyl-6-(3-methyl-1,2,4-oxadiazol-5-yl)-4-oxo-imidazo[1,5-a]thieno[3,2-e]pyrimidine

Versuchsvorschrift

In the same manner 6-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-4,5-dihydro-5-methyl-4-oxo-imidazo[1,5-a]thieno[3,2-e]pyrimidine, m.p. 218°-219° C., was prepared from ethyl 4,5-dihydro-5-methyl- 4-oxo-imidazo[1,5-a]thieno[3,2-e]pyrimidine-6-carboxylate and cyclopropan carboxamide oxime (Compound 18).

Quellen und Nachweise

ORD-Eintrag
ord-54f3dfe9b6914d6fb52f2cbde01bc005
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04866065

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