HCID 178418361, compound → HCID 178460534, compound

HRID 1607579Notes

Reaction equation

HRID 1607579 reaction equation
[C:1]([CH:4]([N:6]1[CH2:11][CH2:10][CH:9]=[C:8]([C:12]2[NH:16][N:15]=[N:14][N:13]=2)[CH2:7]1)[CH3:5])([OH:3])=[O:2].[H][H]>C(OCC)(=O)C.[Pd]>[C:1]([CH:4]([N:6]1[CH2:11][CH2:10][CH2:9][CH:8]([C:12]2[NH:16][N:15]=[N:14][N:13]=2)[CH2:7]1)[CH3:5])([OH:3])=[O:2]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178460533HCID 178460533, compound

Product 1

HCID 178460534HCID 178460534, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 5 (14.9 g, 0.078 mol) in ethyl acetate (160 ml) acetic acid (25 ml) and 5% palladium on charcoal (1.25 g) were added. The mixture was shaken for 24 hours with 3.5 atm. of hydrogen pressure. The mixture was filtered and evaporated to yield the title compound as an oil (12.07 g, 80%).

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-12781eb661b44f09ab8aa6e1f5e48f49
Source dataset
uspto-grants-1989_09
Patent number
US04866077

Reaction notes

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