Fumarate → 5-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

HRID 1607594Notes

Reaction equation

HRID 1607594 reaction equation
[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][CH:3]=1.[C:13]([O-])(=O)/C=C/C([O-])=O>>[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH2:8][N:9]([CH3:13])[CH2:10][CH2:11][CH:12]=2)=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 5460307FumarateHCID 196125135-Methyl-2-(3-pyridyl)-thiazole

Product 1

HCID 196124795-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

Procedure

The title compound was prepared from 88 (2.2 g, 0.013 mol) by the procedure described in Example 49. The crude free base obtained, 89, was converted to the title fumarate, 90. Yield: 0.8 g (0.0032 mol, 25%). M.P. 159°-160° C. Anal. (C12H16N2O2S)C, H, N.

Workup

  1. customThe crude free base obtained

Sources & evidence

ORD record
ord-20be5756eb964adc8d62a76ecbb0ba26
Source dataset
uspto-grants-1989_09
Patent number
US04866077

Reaction notes

Loading…