HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 3-Chloroacetyl-5-(benzyloxy)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 5-Benzyloxyindole | HCID 14624 | — |
| Reactant | Diethylether water | HCID 21584184 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Chloroacetyl-5-(benzyloxy)indole | HCID 10891912 | — |
Reaction Steps
5-(Benzyloxy)indole in dioxane containing pyridine was stirred for 1 hr. at 65° C. under nitrogen while chloroacetyl chloride in dioxane was added dropwise. The reaction mixture was stirred for another 1 hr., then poured into diethyl ether-water. The precipitate was collected by filtration and washed thoroughly with cold Et2O to yield 19, an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04866084 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-80b58256898549e4b404b9fe585b36dc |
| Source note | uspto-grants-1989_09 |