Ammonium Chloride → HCID 10332999, compound

HRID 1607662Notes

Reaction equation

HRID 1607662 reaction equation
[F:1][C:2]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[N+:14]([O-])=O)[C:8]([NH2:10])=[O:9].[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:14][C:13]1[CH:12]=[CH:11][C:7]([C:8]([NH2:10])=[O:9])=[CH:6][C:5]=1[O:4][C:3]1[CH:17]=[CH:18][C:19]([F:21])=[CH:20][C:2]=1[F:1]

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 10085793HCID 10085793, compound

Product 1

HCID 10332999HCID 10332999, compoundYield 91.3%

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 3-(2,4-difluorophenoxy)-4-nitrobenzamide (1 g), iron powder (1 g), and ammonium chloride (0.1 g) in ethanol (20 ml) and water (10 ml) was refluxed with stirring for an hour. The insoluble materials were filtered off and the filtrate was concentrated under reduced pressure to give pale yellow crystals of 4-amino-3-(2,4-difluorophenoxy)benzamide (0.82 g).

Workup

  1. temperaturewas refluxed
  2. filtrationThe insoluble materials were filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c6e356a8e8a64300865585375d73e76d
Source dataset
uspto-grants-1989_09
Patent number
US04866091

Reaction notes

Loading…