Hydrochloric Acid → HCID 10426503, compound

HRID 1607671Notes

Reaction equation

HRID 1607671 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[C:3]=1[O:4][C:5]1[CH:6]=[C:7]([C:14]2([CH3:19])OCC[O:15]2)[CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12].Cl>CC(C)=O>[Cl:1][C:2]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[C:3]=1[O:4][C:5]1[CH:6]=[C:7]([C:14](=[O:15])[CH3:19])[CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10384498HCID 10384498, compound

Product 1

HCID 10426503HCID 10426503, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 2-[3-(2,6-dichlorophenoxy)-4-nitrophenyl]-2-methyl-1,3-dioxolane (3.9 g) and 3N hydrochloric acid (15 ml) in acetone (30 ml) was refluxed for 2.5 hours. The mixture was concentrated under reduced pressure. To the residue were added water (50 ml) and ethyl acetate (60 ml). The organic layer was dried and concentrated to give an amorphous powder of 3'-(2,6-dichlorophenoxy)-4'-nitroacetophenone (3.4 g).

Workup

  1. temperaturewas refluxed for 2.5 hours
  2. concentrationThe mixture was concentrated under reduced pressure
  3. additionTo the residue were added water (50 ml) and ethyl acetate (60 ml)
  4. customThe organic layer was dried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-adf02c198cc84cf5a8ac7680675db4ed
Source dataset
uspto-grants-1989_09
Patent number
US04866091

Reaction notes

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