反应详情

A mixture of 4'-cyano-2'-(2,4-difluorophenoxy)methanesulfonanilide (1.3 g) and concentrated hydrochloric acid (13 ml) in acetic acid (8 ml) was refluxed for 8 hours. The precipitates were filtered, washed with water, dried, and recrystallized from a mixture of ethyl acetate and hexane to give crystals of 3-(2,4-difluorophenoxy)-4-(methanesulfonamido)benzoic acid (0.72 g).

1. temperaturewas refluxed for 8 hours
2. filtrationThe precipitates were filtered
3. washwashed with water
4. customdried
5. customrecrystallized from a mixture of ethyl acetate and hexane