Acetic Acid → HCID 10472595, compound

HRID 1607682Notes

Reaction equation

HRID 1607682 reaction equation
C(C1[CH:13]=[CH:12][C:6]([NH:7][S:8]([CH3:11])(=[O:10])=[O:9])=[C:5]([O:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])[CH:4]=1)#N.Cl.[C:24]([OH:27])(=[O:26])[CH3:25]>>[F:22][C:16]1[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=1[O:14][C:5]1[CH:4]=[C:25]([CH:13]=[CH:12][C:6]=1[NH:7][S:8]([CH3:11])(=[O:9])=[O:10])[C:24]([OH:27])=[O:26]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 10358871N-[4-cyano-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide

Product 1

HCID 10472595HCID 10472595, compound

Procedure

A mixture of 4'-cyano-2'-(2,4-difluorophenoxy)methanesulfonanilide (1.3 g) and concentrated hydrochloric acid (13 ml) in acetic acid (8 ml) was refluxed for 8 hours. The precipitates were filtered, washed with water, dried, and recrystallized from a mixture of ethyl acetate and hexane to give crystals of 3-(2,4-difluorophenoxy)-4-(methanesulfonamido)benzoic acid (0.72 g).

Workup

  1. temperaturewas refluxed for 8 hours
  2. filtrationThe precipitates were filtered
  3. washwashed with water
  4. customdried
  5. customrecrystallized from a mixture of ethyl acetate and hexane

Sources & evidence

ORD record
ord-5dcd9afa03c149bdad9e63bd6b0651e9
Source dataset
uspto-grants-1989_09
Patent number
US04866091

Reaction notes

Loading…