反应详情

温度

80 °C

A mixture of 2'-(2,4-difluorophenoxy)-4'-formylethanesulfonanilide (2 g) and α-triphenylphosphoranylidene-γ-butyrolactone (2.2 g) in dimethyl sulfoxide (10 ml) was stirred at 80° C. for 6 hours. The mixture was dissolved in ethyl acetate, and the resulting mixture was washed with water, dried, and concentrated to dryness. The residue was purified by column chromatography on acetate (1:1) to give a powder of α-[3-(2,4-difluorophenoxy)-4-(methanesulfonamido)benzylidene]-γ-butyrolactone (1.7 g).

1. washthe resulting mixture was washed with water
2. customdried
3. concentrationconcentrated to dryness
4. customThe residue was purified by column chromatography on acetate (1:1)