Hydrochloric Acid → HCID 18606035, compound

HRID 1607710Notes

Reaction equation

HRID 1607710 reaction equation
C([O:5][C:6](=[O:31])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12]([N:14]([CH3:30])[NH:15][CH:16]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:13])(C)(C)C.Cl>CCOCC>[CH3:30][N:14]([C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:6]([OH:31])=[O:5])=[O:13])[NH:15][CH:16]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18606052HCID 18606052, compound

Product 1

HCID 18606035HCID 18606035, compoundYield 86.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 0.4 g of the product of Example 1 in 50 ml anhydrous ether was treated with dry HCl gas at 0° C. for two hours. Solvent was evaporated to dryness. Purification of the crude product through Dowex 50 X 2-100, resin gave 0.3 g of product.

Workup

  1. customSolvent was evaporated to dryness
  2. customPurification of the crude product through Dowex 50 X 2-100, resin

Sources & evidence

ORD record
ord-4e45a7e23b2e4c14964155791e2207e2
Source dataset
uspto-grants-1989_09
Patent number
US04866173

Reaction notes

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