Sodium Carbonate → HCID 14579447, compound

HRID 1607729Notes

Reaction equation

Cl.[NH2:2][CH2:3][CH:4]([C:6]1[CH:16]=[CH:15][C:9]([O:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:8][CH:7]=1)[CH3:5].C(=O)([O-])[O-].[Na+].[Na+].[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=1[S:31](Cl)(=[O:33])=[O:32]>O>[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=1[S:31]([NH:2][CH2:3][CH:4]([C:6]1[CH:16]=[CH:15][C:9]([O:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:8][CH:7]=1)[CH3:5])(=[O:33])=[O:32]

Participants

Conditions

Temperature: 80 °C

Procedure

A mixture of 2.95 g of (±)-4-(2-amino-1-methylethyl)phenoxyacetic acid hydrochloride, 3.82 g of sodium carbonate, 30 ml of water and 3.1 g of 2,5-dichlorophenylsulfonyl chloride is stirred at 80° C. for 3 hours. The reaction mixture is treated in the same manner as described in Example 43, whereby (±)-4-[2-(2,5-dichlorophenyl)sulfonylamino-1-methylethyl)phenoxyacetic acid is obtained.

Workup

additionThe reaction mixture is treated in the same manner

Sources & evidence

ORD record: ord-54a0daa4f87e49d2a9997135a8cd7bc1
Source dataset: uspto-grants-1989_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04866196

Reaction notes

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