反应详情

To a solution of methyl 2-chloromethyl-2,6-bis(benzylideneamino)hexanoate (2.85 g, 7.4 mmol) in ether (6 ml), is added 1N HCl (20 ml) under vigorous stirring. The reaction mixture is stirred overnight at room temperature and then extracted with ether. The aqueous phase is evaporated to dryness under vacuo to afford methyl 2-chloromethyl-2,6-diaminohexanoate dihydrochloride as an oily and hygroscopic residue (2.05 g).

1. extractionextracted with ether
2. customThe aqueous phase is evaporated to dryness under vacuo