Ethanol → Vancomycin monohydrochloride

Participants

Reaction Steps

The Vancomycin/imidazole crystals (0.5 g) were dissolved in water (2.5 ml) by the addition of hydochloric acid (6N) to pH 2.0 and the solution added to ethyl alcohol (25 ml). After 2 h at 0° C. the precipitate was harvested by filtration, washed with diethyl ether (5 ml) and dried in vacuo to give Vancomycin hydrochloride (0.44 g, Vancomycin assay 1.04 g/g).

Provenance & Evidence