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HRID1607969

反应详情

EQUATION

反应方程式

HRID 1607969 的结构方程式

REACTANTS

反应物

2
反应SMILES：CCO
HCID702

Ethanol

C2H6O

反应SMILES：CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O.c1c[nH]cn1
HCID86743394

未命名化合物

PRODUCTS

产物

1
反应SMILES：CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O.Cl
HCID6420023

Vancomycin monohydrochloride

C66H76Cl3N9O24

收率 179.7%

AUXILIARIES

试剂、催化剂与溶剂

2
反应SMILES：Cl
溶剂HCID313

Hydrochloric Acid

ClH

反应SMILES：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

The Vancomycin/imidazole crystals (0.5 g) were dissolved in water (2.5 ml) by the addition of hydochloric acid (6N) to pH 2.0 and the solution added to ethyl alcohol (25 ml). After 2 h at 0° C. the precipitate was harvested by filtration, washed with diethyl ether (5 ml) and dried in vacuo to give Vancomycin hydrochloride (0.44 g, Vancomycin assay 1.04 g/g).

WORKUP

后处理

  1. filtrationAfter 2 h at 0° C. the precipitate was harvested by filtration
  2. washwashed with diethyl ether (5 ml)
  3. customdried in vacuo