反应详情

温度

45 °C

Sulfuric acid (46.0 g) was placed in a 3-liter 3-neck flask and heated to 45° C. A mixture of acrylonitrile (94.5g) and cyclohexanol (180.2g) was prepared and added to the flask simultaneously with additional sulfuric acid (95.8%, 322.3 g) keeping the temperature at 45°-55° C. At the end of the addition, the brown solution was heated to 60° C. for 3 hours. The mixture was then poured into 3 liters of ice water with constant stirring. The white precipitate formed was filtered, washed with water until filtrate is no longer acidic and dried in a vacuum oven at 55° C. to yield N-cyclohexylacrylamide (242.4 g, 88%); m.p. 109°-110° C.

1. customwas prepared
2. customat 45°-55° C
3. additionAt the end of the addition
4. temperaturethe brown solution was heated to 60° C. for 3 hours
5. customThe white precipitate formed
6. filtrationwas filtered
7. washwashed with water until filtrate
8. customdried in a vacuum oven at 55° C.