反应详情

温度

80 °C

A mixture of ethyl 4-hydroxy-2-oxo-1-pyrrolidineacetate (0.5 g) and glycinamide (0.6 g) was stirred under nitrogen at 80° C. for 4 hours. After cooling, the mixture was chromatographed on a silica gel column, by eluting with dichloromethane/methanol 7:3, affording the title compound (250 mg).

1. temperatureAfter cooling
2. customthe mixture was chromatographed on a silica gel column
3. washby eluting with dichloromethane/methanol 7:3