Dicyclohexylcarbodiimide → 1,5-Dihydro-4,1-benzoxazepin-2(3H)-one

HRID 1608142Notes

Reaction equation

HRID 1608142 reaction equation
[NH2:1][C:2]1[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=1[CH2:4][O:5][CH2:6][C:7](O)=[O:8].C1(N=C=NC2CCCCC2)CCCCC1>CO>[O:8]=[C:7]1[CH2:6][O:5][CH2:4][C:3]2[CH:10]=[CH:11][CH:12]=[CH:13][C:2]=2[NH:1]1

Participants

4

Reactant 2

HCID 10868DicyclohexylcarbodiimideHCID 19836746HCID 19836746, compound

Product 1

HCID 158877541,5-Dihydro-4,1-benzoxazepin-2(3H)-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 g o-amino-benzyloxy acetic acid and 1.1 g dicyclohexyl carbodiimide were stirred in 15 ml refluxing methanol for 8 hours. The mixture was evaporated, and the residue was stirred with 50 ml acetone and filtered, whereafter the filtrate was evaporated to give the title compound.

Workup

  1. customThe mixture was evaporated
  2. filtrationfiltered, whereafter the filtrate
  3. customwas evaporated

Sources & evidence

ORD record
ord-70d73d4557524fdab50fb8ca6434fed6
Source dataset
uspto-grants-1989_09
Patent number
US04870073

Reaction notes

Loading…