HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 4-(2-Sulfoethyl)-1-phenylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | 2-Bromoethanesulfonic acid, sodium salt | HCID 23666797 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2-Sulfoethyl)-1-phenylpiperazine | HCID 14834683 | — |
Reaction Steps
A 3.25 g quantity (20 mmols) of 1-phenylpiperazine is dissolved in 10 ml of water, and a solution of 4.3 g (20 mmols) of sodium 2-bromoethanesulfonate in 10 ml of water is added dropwise thereto at room temperature with stirring. The mixture is subjected to reaction at room temperature for 1 hour and then at 70° C. overnight, and cooled. The crystals precipitated are collected by filtration and recrystallized from water-acetone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04870078 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-5c5d523a8df2484cb52f2cd0eb151ee6 |
| Source note | uspto-grants-1989_09 |