Propane sultone → HCID 14834685, compound

HRID 1608169Notes

Reaction equation

HRID 1608169 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[CH2:16]1[CH2:22][S:19](=[O:21])(=[O:20])[O:18][CH2:17]1>CC(C)=O>[S:19]([CH2:22][CH2:16][CH2:17][N:13]1[CH2:12][CH2:11][N:10]([C:7]2[CH:6]=[CH:5][C:4]([C:1](=[O:3])[CH3:2])=[CH:9][CH:8]=2)[CH2:15][CH2:14]1)([OH:21])(=[O:20])=[O:18]

Participants

4

Reactant 2

HCID 14264Propane sultoneHCID 97269Piperazin-4-ylacetophenone

Product 1

HCID 14834685HCID 14834685, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A 4.1 g quantity (20 mmols) of 1-(p-acetylphenyl)piperazine is dissolved in 40 ml of acetone, and a solution of 2.44 g (20 mmols) of 1,3-propanesultone in 10 ml of acetone is added dropwise thereto at room temperature with stirring. After reaction at room temperature with stirring overnight, the yellow crystals precipitated are collected by filtration and then recrystallized from water-acetone.

Workup

  1. customAfter reaction at room temperature
  2. stirringwith stirring overnight
  3. customthe yellow crystals precipitated
  4. filtrationare collected by filtration
  5. customrecrystallized from water-acetone

Sources & evidence

ORD record
ord-3c3d0ec0cca741019105638558cda709
Source dataset
uspto-grants-1989_09
Patent number
US04870078

Reaction notes

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