5-Chloro-4-dimethylamino-2-methoxybenzoic acid → HCID 14881853, compound

HRID 1608194Notes

Reaction equation

HRID 1608194 reaction equation
[NH2:1][CH2:2][CH:3]1[O:8][CH2:7][CH2:6][N:5]([CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[CH2:4]1.[Cl:20][C:21]1[C:22]([N:32]([CH3:34])[CH3:33])=[CH:23][C:24]([O:30][CH3:31])=[C:25]([CH:29]=1)[C:26](O)=[O:27]>>[Cl:20][C:21]1[C:22]([N:32]([CH3:33])[CH3:34])=[CH:23][C:24]([O:30][CH3:31])=[C:25]([CH:29]=1)[C:26]([NH:1][CH2:2][CH:3]1[O:8][CH2:7][CH2:6][N:5]([CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=2)[CH2:4]1)=[O:27]

Participants

3

Reactant 2

HCID 110752025-Chloro-4-dimethylamino-2-methoxybenzoic acidHCID 148818524-[3-(4-Chlorophenoxy)propyl]-2-morpholinemethanamine

Product 1

HCID 14881853HCID 14881853, compound

Procedure

The hemihydrate of the title compound is prepared in substantially the same manner as in Example 6(1), using 2-aminomethyl-4-[3-(4-chlorophenoxy)propyl]morpholine and 5-chloro-4-dimethylamino-2-methoxybenzoic acid, respectively, in place of 2-aminomethyl-4-(4-cyanobenzyl)morpholine and 4-amino-5-chloro-2-methoxybenzoic acid in Example 6(1), mp 128°-130° C. (recrystallized from ethanol).

Workup

  1. customrespectively, in place of 2-aminomethyl-4-(4-cyanobenzyl)morpholine and 4-amino-5-chloro-2-methoxybenzoic acid in Example 6(1), mp 128°-130° C. (recrystallized from ethanol)

Sources & evidence

ORD record
ord-6878f2d6e25442dca34028244df17091
Source dataset
uspto-grants-1989_09
Patent number
US04870074

Reaction notes

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